Abstract
An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Breast Neoplasms / diagnostic imaging
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Breast Neoplasms / drug therapy*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Drug Screening Assays, Antitumor
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Halogenation
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Hydrophobic and Hydrophilic Interactions
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Mice
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Molecular Structure
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Nanoparticles / administration & dosage
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Nanoparticles / chemistry
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Optical Imaging
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Organophosphonates / administration & dosage
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Organophosphonates / chemistry
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Organophosphonates / pharmacology*
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Particle Size
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Photochemotherapy*
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Photosensitizing Agents / administration & dosage
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology*
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Polymers / administration & dosage
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Polymers / chemistry
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Polymers / pharmacology*
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Porphyrins / administration & dosage
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Porphyrins / chemistry
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Porphyrins / pharmacology*
Substances
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Antineoplastic Agents
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Organophosphonates
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Photosensitizing Agents
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Polymers
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Porphyrins
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chlorin