Seroprevalence of cytomegalovirus and its coinfection with Epstein-Barr virus in adult residents from Manaus: a population-based study

Rev Soc Bras Med Trop. 2020 Jan 27:53:e20190363. doi: 10.1590/0037-8682-0363-2019. eCollection 2020.

Abstract

Introduction: This study assessed the seroprevalence of cytomegalovirus, associated factors, and Epstein-Barr virus coinfection among adult residents of Manaus.

Methods: Using a cross-sectional study design, we collected blood samples from 136 individuals in a household survey in 2016. Prevalence ratios were calculated using Poisson regression.

Results: Cytomegalovirus and Epstein-Barr virus seroprevalences were 67.6% (95% CI: 9.7-75.6%) and 97.8% (95% CI: 95.3-100.0%), respectively. Coinfection was observed in 66.2% (95% CI: 58.1-74.2%) of participants. Bivariate analysis showed no statistical association.

Conclusions: Seroprevalences were high among participants and approximately 7 out of 10 individuals had cytomegalovirus and Epstein-Barr virus coinfection.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Viral / blood*
  • Brazil / epidemiology
  • Coinfection
  • Cross-Sectional Studies
  • Cytomegalovirus / immunology*
  • Cytomegalovirus Infections / diagnosis
  • Cytomegalovirus Infections / epidemiology*
  • Epstein-Barr Virus Infections / diagnosis
  • Epstein-Barr Virus Infections / epidemiology*
  • Female
  • Herpesvirus 4, Human / immunology*
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Risk Factors
  • Seroepidemiologic Studies
  • Socioeconomic Factors
  • Young Adult

Substances

  • Antibodies, Viral