Distal Alkenyl C-H Functionalization via the Palladium/Norbornene Cooperative Catalysis

J Am Chem Soc. 2020 Feb 12;142(6):2715-2720. doi: 10.1021/jacs.9b11479. Epub 2020 Feb 3.

Abstract

A distal-selective alkenyl C-H arylation method is reported through a directed palladium/norbornene (Pd/NBE) cooperative catalysis. The key is to use an appropriate combination of the directing group and the NBE cocatalyst. A range of acyclic and cyclic cis-olefins are suitable substrates, and the reaction is operated under air with excellent site-selectivity. Preliminary mechanistic studies are consistent with the proposed Pd/NBE-catalyzed C-H activation instead of the Heck pathway. Initial success on distal alkylation has also been achieved using MeI and methyl bromoacetate as electrophiles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Alkylation
  • Catalysis
  • Molecular Structure
  • Norbornanes / chemistry*
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Norbornanes
  • 2-norbornene
  • Palladium