Abstract
In this issue of Blood, Pan et al highlight their approach toward dual-antigen chimeric antigen receptor (CAR) T-cell targeting in an effort to reduce the risk of immune escape in pediatric B-cell acute lymphoblastic leukemia (B-ALL). They demonstrate the feasibility of sequentially administering CD19 CAR T cells followed by CD22 CAR T cells alongside the safety, toxicity, and efficacy of such a model. Their observation suggests that sequential CAR T-cell targeting strategies may be safe and effective and provides proof-of-concept of a potential strategy that may allow for dual-antigen CAR T-cell targeting.
MeSH terms
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Antigens, CD19
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Child
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Humans
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Immunotherapy, Adoptive*
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Receptors, Chimeric Antigen*
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T-Lymphocytes / immunology
Substances
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Antigens, CD19
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Receptors, Chimeric Antigen