Neonatal Assessment of Infants with Heterotaxy

Gabrielle C Geddes; Sai-Suma Samudrala; Michael G Earing

doi:10.1016/j.clp.2019.10.011

Neonatal Assessment of Infants with Heterotaxy

Clin Perinatol. 2020 Mar;47(1):171-182. doi: 10.1016/j.clp.2019.10.011. Epub 2019 Oct 31.

Authors

Gabrielle C Geddes¹, Sai-Suma Samudrala², Michael G Earing³

Affiliations

¹ Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA; Herma Heart Institute, Children's Hospital of Wisconsin, 9000 West Wisconsin Avenue, MS#716, Milwaukee, WI 53226, USA. Electronic address: [email protected].
² Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
³ Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA; Herma Heart Institute, Children's Hospital of Wisconsin, 9000 West Wisconsin Avenue, MS#716, Milwaukee, WI 53226, USA; Section of Adult Cardiovascular Medicine, Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.

PMID: 32000924
DOI: 10.1016/j.clp.2019.10.011

Abstract

Heterotaxy is a generalized term for patients who have an abnormality of laterality that cannot be described as situs inversus. Infants with heterotaxy can have significant anatomic and medical complexity and require personalized, specialized care, including comprehensive anatomic assessment. Common and rare anatomic findings are reviewed by system to help guide a thorough phenotypic evaluation. General care guidelines and considerations unique to this patient population are included. Future directions for this unique patient population, particularly in light of improved neonatal survival, are discussed.

Keywords: Heterotaxy; Isomerism; Ivemark syndrome; Laterality defect; Situs ambiguus; Situs inversus.

Publication types

Review

MeSH terms

Diagnosis, Differential
Heterotaxy Syndrome / diagnosis*
Heterotaxy Syndrome / therapy*
Humans
Infant, Newborn
Neonatal Screening
Rare Diseases / diagnosis*
Rare Diseases / therapy*