Elderly woman with subacute lower limb weakness and rapid systemic decline

Charis Wong; Adrian J Wills; Neshika Samarasekera; Donald Noble; Colin Smith; Richard Davenport

doi:10.1136/practneurol-2019-002476

Elderly woman with subacute lower limb weakness and rapid systemic decline

Pract Neurol. 2020 Apr;20(2):168-174. doi: 10.1136/practneurol-2019-002476. Epub 2020 Jan 30.

Authors

Charis Wong^{1

2}, Adrian J Wills³, Neshika Samarasekera⁴, Donald Noble⁵, Colin Smith^{4

6}, Richard Davenport^{4

7}

Affiliations

¹ Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK [email protected].
² Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK.
³ Department of Neurology, Queens Medical Centre, Nottingham, UK.
⁴ Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
⁵ Department of General Medicine, St John's Hospital, Livingston, UK.
⁶ Department of Neuropathology, University of Edinburgh, Edinburgh, UK.
⁷ Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.

PMID: 32001663
DOI: 10.1136/practneurol-2019-002476

Abstract

A 74-year-old woman developed bilateral leg weakness, with fluctuating cognitive and systemic symptoms that progressed despite treatment. Her diagnosis was confirmed at autopsy. Her case was discussed at the Edinburgh Clinical Neurology Course 2019 Clinicopathological Conference.

Keywords: clinical neurology; neuropathology.

Publication types

Case Reports

MeSH terms

Aged
Disease Progression*
Fatal Outcome
Female
Humans
Lower Extremity / pathology
Lymphoma, B-Cell / blood
Lymphoma, B-Cell / complications
Lymphoma, B-Cell / diagnostic imaging*
Muscle Weakness / blood
Muscle Weakness / diagnostic imaging*
Muscle Weakness / etiology
Paraplegia / blood
Paraplegia / diagnostic imaging*
Paraplegia / etiology
Time Factors