Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis

Zheng Liu; Jianjun Chen; Lei Cheng; Huabin Li; Shixi Liu; Hongfei Lou; Jianbo Shi; Ying Sun; Dehui Wang; Chengshuo Wang; Xiangdong Wang; Yongxiang Wei; Weiping Wen; Pingchang Yang; Qintai Yang; Gehua Zhang; Yuan Zhang; Changqing Zhao; Dongdong Zhu; Li Zhu; Fenghong Chen; Yi Dong; Qingling Fu; Jingyun Li; Yanqing Li; Chengyao Liu; Feng Liu; Meiping Lu; Yifan Meng; Jichao Sha; Wenyu She; Lili Shi; Kuiji Wang; Jinmei Xue; Luoying Yang; Min Yin; Lichuan Zhang; Ming Zheng; Bing Zhou; Luo Zhang

doi:10.4168/aair.2020.12.2.176

Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis

Allergy Asthma Immunol Res. 2020 Mar;12(2):176-237. doi: 10.4168/aair.2020.12.2.176.

Authors

Zheng Liu^#¹, Jianjun Chen^#², Lei Cheng^#^{3

4}, Huabin Li^#⁵, Shixi Liu^#⁶, Hongfei Lou^#^{7

8}, Jianbo Shi^#⁹, Ying Sun^#¹⁰, Dehui Wang^#⁵, Chengshuo Wang^#^{7

8}, Xiangdong Wang^#⁸, Yongxiang Wei^#¹¹, Weiping Wen^#^{9

12}, Pingchang Yang^#¹³, Qintai Yang^#¹⁴, Gehua Zhang^#¹⁴, Yuan Zhang^#^{7

8

15}, Changqing Zhao^#¹⁶, Dongdong Zhu^#¹⁷, Li Zhu^#¹⁸, Fenghong Chen⁹, Yi Dong⁸, Qingling Fu⁹, Jingyun Li⁸, Yanqing Li⁵, Chengyao Liu⁷, Feng Liu⁶, Meiping Lu³, Yifan Meng^{7

8}, Jichao Sha¹⁷, Wenyu She^{8

15}, Lili Shi¹, Kuiji Wang^{7

8}, Jinmei Xue¹⁶, Luoying Yang¹⁴, Min Yin^{3

4}, Lichuan Zhang¹¹, Ming Zheng^{7

8}, Bing Zhou¹⁹, Luo Zhang^{7

8

20}

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
⁴ International Centre for Allergy Research, Nanjing Medical University, Nanjing, China.
⁵ Department of Otolaryngology, Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China.
⁶ Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, China.
⁷ Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
⁸ Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
⁹ Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
¹⁰ Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
¹¹ Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
¹² Otorhinolaryngology Hospital, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
¹³ Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
¹⁴ Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
¹⁵ Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
¹⁶ Department of Otolaryngology Head and Neck Surgery, The Second Hospital, Shanxi Medical University, Taiyuan, China.
¹⁷ Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
¹⁸ Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, China.
¹⁹ Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [email protected].
²⁰ Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [email protected].

^# Contributed equally.

Abstract

The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology Group. Chronic rhinosinusitis (CRS) affects approximately 8% of Chinese adults. The inflammatory and remodeling mechanisms of CRS in the Chinese population differ from those observed in the populations of European descent. Recently, precision medicine has been used to treat inflammation by targeting key biomarkers that are involved in the process. However, there are no CRS guidelines or a consensus available from China that can be shared with the international academia. The guidelines presented in this paper cover the epidemiology, economic burden, genetics and epigenetics, mechanisms, phenotypes and endotypes, diagnosis and differential diagnosis, management, and the current status of CRS in China. These guidelines-with a focus on China-will improve the abilities of clinical and medical staff during the treatment of CRS. Additionally, they will help international agencies in improving the verification of CRS endotypes, mapping of eosinophilic shifts, the identification of suitable biomarkers for endotyping, and predicting responses to therapies. In conclusion, these guidelines will help select therapies, such as pharmacotherapy, surgical approaches and innovative biotherapeutics, which are tailored to each of the individual CRS endotypes.

Keywords: China; Chronic, sinusitis; biomarkers; diagnosis; endotypes; epigenesis; guideline; inflammation; management; phenotype.

Publication types

Review