Survival of osteosarcoma patients following diagnosis of synchronous skip metastases

Peiming Yang; Magdalena Gilg; Scott Evans; Francesca Totti; Jonathan Stevenson; Lee Jeys; Michael Parry

doi:10.1016/j.jor.2019.10.003

Survival of osteosarcoma patients following diagnosis of synchronous skip metastases

J Orthop. 2019 Oct 24:18:121-125. doi: 10.1016/j.jor.2019.10.003. eCollection 2020 Mar-Apr.

Authors

Peiming Yang¹, Magdalena Gilg¹, Scott Evans¹, Francesca Totti¹, Jonathan Stevenson¹, Lee Jeys¹, Michael Parry¹

Affiliation

¹ Royal Orthopaedic Hospital NHS Foundation Trust, UK.

Abstract

Background: We aim to investigate the prognostic implications of synchronous skip metastases in osteosarcoma by presenting the largest single centre series to date.

Methods: Retrospective study of 21 osteosarcoma patients with skip metastases treated between 1983 and 2004.

Results: No statistical difference in overall survival was demonstrated when comparing presence of lung metastases to those without (p = 0.859). No statistical difference was found in overall survival according to age group (<18yrs vs >18yrs; p = 0.126), or to percentage chemotherapy-induced bone necrosis (<90% vs >90%; p = 0.056).

Conclusions: The presence of skip metastases confers a very poor prognosis as an independent variable.

Level of evidence: III.

Keywords: Osteosarcoma; Skip metastases; Survival; Synchronous.