Dietary Methionine in T Cell Biology and Autoimmune Disease

Shuang Tang; Xiaoling Li; Jason W Locasale

doi:10.1016/j.cmet.2020.01.007

Dietary Methionine in T Cell Biology and Autoimmune Disease

Cell Metab. 2020 Feb 4;31(2):211-212. doi: 10.1016/j.cmet.2020.01.007.

Authors

Shuang Tang¹, Xiaoling Li², Jason W Locasale³

Affiliations

¹ Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC 27709, USA.
² Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC 27709, USA. Electronic address: [email protected].
³ Duke University, Durham, NC 27560, USA. Electronic address: [email protected].

PMID: 32023442
DOI: 10.1016/j.cmet.2020.01.007

Abstract

Dietary methionine and its subsequent metabolism have profound effects on metabolic disease, cancer, and healthspan. In this issue of Cell Metabolism, Roy et al. (2020) report methionine as a nutritional factor for activated T cells that maintains H3K4 methylation and mediates functions that affect autoimmune disease.

Publication types

Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Autoimmune Diseases*
Diet
Epigenesis, Genetic
Humans
Methionine*
T-Lymphocytes, Helper-Inducer

Substances

Methionine

Grants and funding

ZIA ES102205/ImNIH/Intramural NIH HHS/United States