Role of DNA-detection-based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials

Javier Gandasegui; María Martínez-Valladares; Berta Grau-Pujol; Alejandro J Krolewiecki; Rafael Balaña-Fouce; Woyneshet Gelaye; Lisette van Lieshout; Stella Kepha; Inácio Mandomando; José Muñoz; Stopping Transmission Of intestinal Parasites (STOP) project consortium

doi:10.1371/journal.pntd.0007931

Role of DNA-detection-based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials

PLoS Negl Trop Dis. 2020 Feb 6;14(2):e0007931. doi: 10.1371/journal.pntd.0007931. eCollection 2020 Feb.

Authors

Javier Gandasegui^{1

2}, María Martínez-Valladares^{3

4}, Berta Grau-Pujol^{1

2

5}, Alejandro J Krolewiecki^{1

6}, Rafael Balaña-Fouce⁷, Woyneshet Gelaye⁸, Lisette van Lieshout⁹, Stella Kepha^{10

11

12}, Inácio Mandomando^{2

13}, José Muñoz¹; Stopping Transmission Of intestinal Parasites (STOP) project consortium

Affiliations

¹ ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
² Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
³ Instituto de Ganadería de Montaña (CSIC-Universidad de León), Grulleros, León, Spain.
⁴ Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, Campus de Vegazana, León, Spain.
⁵ Fundación Mundo Sano, Buenos Aires, Argentina.
⁶ Instituto de Investigaciones de Enfermedades Tropicales, Universidad Nacional de Salta, Sede regional Orán, Argentina.
⁷ Departamento de Ciencias Biomédicas, Universidad de León, León, Spain.
⁸ Department of Medical Laboratory Science, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
⁹ Departement of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
¹⁰ Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
¹¹ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medical Medicine, London, United Kingdom.
¹² Pwani University Biosciences Research Centre (PUBRec), Pwani University, Kilifi, Kenya.
¹³ Instituto Nacional de Saúde (INS), Ministério da Saúde, Maputo, Mozambique.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthelmintics / administration & dosage*
DNA, Helminth / genetics*
Drug Monitoring
Drug Resistance
Helminthiasis / drug therapy*
Helminthiasis / parasitology*
Helminthiasis / transmission
Helminths / classification
Helminths / drug effects*
Helminths / genetics*
Helminths / isolation & purification
Humans
Polymerase Chain Reaction
Soil / parasitology*

Substances

Anthelmintics
DNA, Helminth
Soil

Grants and funding

The Stopping Transmission Of intestinal Parasites (STOP) project is part of the EDCTP2 programme supported by the European Union (grant number RIA2017NCT-1845 — STOP). JG is personally supported by Ramon Areces Foundation, Spain; MMV by the Spanish ‘Ramón y Cajal’ Programme, Ministry of Economy and Competitiveness (RYC-2015-18368); and SK is supported by DELTAS Africa Initiative grant # DEL-15-011 to THRiVE-2. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.