Extracellular vesicles from myelodysplastic mesenchymal stromal cells induce DNA damage and mutagenesis of hematopoietic stem cells through miRNA transfer

Leukemia. 2020 Aug;34(8):2249-2253. doi: 10.1038/s41375-020-0738-8. Epub 2020 Feb 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DEAD-box RNA Helicases / genetics
  • DNA Damage*
  • Extracellular Vesicles / physiology*
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • Mesenchymal Stem Cells / physiology*
  • MicroRNAs
  • Mutagenesis*
  • Myelodysplastic Syndromes / etiology
  • Myelodysplastic Syndromes / genetics
  • Myelodysplastic Syndromes / pathology*
  • Ribonuclease III / genetics

Substances

  • MicroRNAs
  • DICER1 protein, human
  • Ribonuclease III
  • DEAD-box RNA Helicases