New Drugs for NASH and HIV Infection: Great Expectations for a Great Need

Hepatology. 2020 May;71(5):1831-1844. doi: 10.1002/hep.31177.

Abstract

In recent years, there has been an increasing number of clinical trials for the treatment of nonalcoholic steatohepatitis (NASH). People living with human immunodeficiency virus (PLWH) are commonly excluded from these studies, usually due to concerns over drug-drug interactions associated with antiretroviral therapy. The Steatohepatitis in HIV Emerging Research Network, a group of international experts in hepatology and infectious diseases, discusses our current understanding on the interaction between human immunodeficiency virus and NASH, and the issues related to the inclusion of PLWH in NASH clinical trials. Recent trials addressing NASH treatment in PLWH are discussed. The risk of drug-drug interactions between antiretroviral therapy and aramchol, cenicriviroc, elafibranor, obeticholic acid and resmetirom (MGL-3196), which are currently in phase 3 trials for the treatment of NASH, are reviewed. A model for trial design to include PLWH is proposed, strongly advocating for the scientific community to include this group as a subpopulation within studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Retroviral Agents / therapeutic use
  • Chalcones / therapeutic use
  • Chenodeoxycholic Acid / analogs & derivatives
  • Chenodeoxycholic Acid / therapeutic use
  • Cholic Acids / therapeutic use
  • Clinical Trials, Phase III as Topic
  • Drug Interactions
  • HIV Infections / complications*
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • Humans
  • Imidazoles / therapeutic use
  • Non-alcoholic Fatty Liver Disease / complications*
  • Non-alcoholic Fatty Liver Disease / drug therapy*
  • Non-alcoholic Fatty Liver Disease / epidemiology
  • Propionates / therapeutic use
  • Pyridazines / therapeutic use
  • Sulfoxides / therapeutic use
  • Uracil / analogs & derivatives
  • Uracil / therapeutic use

Substances

  • 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid
  • Anti-Retroviral Agents
  • Chalcones
  • Cholic Acids
  • Imidazoles
  • Propionates
  • Pyridazines
  • Sulfoxides
  • obeticholic acid
  • Chenodeoxycholic Acid
  • cenicriviroc
  • Uracil
  • aramchol
  • resmetirom