Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a

Stephanie Popping; Rosanne Verwijs; Lize Cuypers; Mark A Claassen; Guido E van den Berk; Anja De Weggheleire; Joop E Arends; Anne Boerekamps; Richard Molenkamp; Marion P Koopmans; Annelies Verbon; Charles A B Boucher; Bart J Rijnders; David A M C van de Vijver; Dutch Acute HCV in HIV Study Investigators

doi:10.1093/cid/ciaa145

Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a

Clin Infect Dis. 2020 Nov 5;71(8):e215-e217. doi: 10.1093/cid/ciaa145.

Authors

Stephanie Popping¹, Rosanne Verwijs², Lize Cuypers^{3

4}, Mark A Claassen⁵, Guido E van den Berk⁶, Anja De Weggheleire⁷, Joop E Arends⁸, Anne Boerekamps², Richard Molenkamp¹, Marion P Koopmans¹, Annelies Verbon², Charles A B Boucher¹, Bart J Rijnders², David A M C van de Vijver¹; Dutch Acute HCV in HIV Study Investigators

Collaborators

Dutch Acute HCV in HIV Study Investigators:
Fanny Lauw, Dirk Posthouwer, Sebastiaan Hullegie, Wouter Bierman, Anthonius Dofferhof, Gert Jan Kootstra, Eliane Leyten, Jan den Hollander, Marjo van Kasteren, Robin Soutekouw, Heidi Ammerlaan, Eric Florence

Affiliations

¹ Department of Viroscience, Erasmus Medical Center , University Medical Center, Rotterdam, The Netherlands.
² Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands.
³ Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Kristelijke Universiteit Leuven, Leuven, Belgium.
⁴ Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
⁵ Department of Internal Medicine and Infectious Diseases, Rijnstate Ziekenhuis, Arnhem, The Netherlands.
⁶ Department of Internal Medicine and Infectious Diseases, Onze lieve vrouwe gasthhuis, Amsterdam, The Netherlands.
⁷ Department of Clinical Science, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
⁸ Department of Internal Medicine and Infectious Diseases, Universitair Medisch Centrum Utrecht, Utrecht University, Utrecht, The Netherlands.

Abstract

The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

Keywords: HIV co-infected MSM; hepatitis C virus; phylogenetic analysis; resistant associated substitutions; the WHO 2030 elimination goals.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / pharmacology
Antiviral Agents / therapeutic use
Drug Resistance, Viral / genetics
Genotype
Hepacivirus / genetics
Hepatitis C* / drug therapy
Hepatitis C* / epidemiology
Hepatitis C, Chronic* / drug therapy
Homosexuality, Male
Humans
Male
Phylogeny
Sexual and Gender Minorities*
Viral Nonstructural Proteins / genetics

Substances

Antiviral Agents
Viral Nonstructural Proteins