Endoglin: Beyond the Endothelium

Biomolecules. 2020 Feb 12;10(2):289. doi: 10.3390/biom10020289.

Abstract

Keywords: endoglin; CD105 TGF-β; BMP9; ALK-1; TRC105; tumor microenvironment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Activin Receptors, Type II / metabolism
  • Adaptive Immunity
  • Animals
  • Antibodies, Monoclonal / pharmacology
  • Clinical Trials as Topic
  • Endoglin / metabolism*
  • Endothelium / metabolism*
  • Epithelial Cells / metabolism
  • Fibrosis
  • Growth Differentiation Factor 2 / metabolism
  • Hematopoiesis
  • Humans
  • Immunity, Innate
  • Ligands
  • Mesenchymal Stem Cells / cytology
  • Mice
  • Neoplasms / metabolism
  • Neovascularization, Pathologic
  • Phosphorylation
  • Signal Transduction
  • Transforming Growth Factor beta / metabolism*
  • Tumor Microenvironment

Substances

  • Antibodies, Monoclonal
  • ENG protein, human
  • Endoglin
  • GDF2 protein, human
  • Growth Differentiation Factor 2
  • Ligands
  • Transforming Growth Factor beta
  • ACVRL1 protein, human
  • Activin Receptors, Type II
  • carotuximab