Development of an abbreviated symptom score for the neonatal abstinence syndrome

J Perinatol. 2020 Jul;40(7):1031-1040. doi: 10.1038/s41372-020-0606-4. Epub 2020 Feb 19.

Abstract

Objective: We sought a shortened MOTHER neonatal abstinence syndrome (NAS) and Finnegan score that would retain comparable performance characteristics of the full instrument.

Study design: Retrospective cohort.

Results: In total, 124,170 MOTHER NAS scores between August 2007 and May 2016 from 775 infants (≥36 weeks) were examined. Classification and regression tree model identified the most important subsets of the scored variables. A 9-element shortened scale yielded >90% sensitivity and specificity to predict clinical endpoints based on the full 19-element MOTHER NAS score. Conversion of the data sets to the Finnegan score, and applying the same procedure resulted in a nine-element score with similar performance characteristics.

Conclusion: Shortened scoring instruments were identified with the high-predictive power for clinical endpoints based on the 19-element full MOTHER NAS score. There was no substantial variation in performance for age, supporting the current practice of utilizing a single scoring tool regardless of postnatal age.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cohort Studies
  • Female
  • Humans
  • Infant, Newborn
  • Mothers
  • Neonatal Abstinence Syndrome* / diagnosis
  • Retrospective Studies
  • Sensitivity and Specificity