Local allergic rhinitis: nasal allergen provocation testing as a good tool in the differential diagnosis

Int J Occup Med Environ Health. 2020 Mar 13;33(2):241-246. doi: 10.13075/ijomeh.1896.01503. Epub 2020 Feb 24.

Abstract

Local allergic rhinitis (LAR) is a specific phenotype of allergic rhinitis. One characteristic feature of LAR is a medical history indicative of an allergic disease, negative skin-prick test results, undetectable levels of specific IgE, and a positive allergen-specific nasal provocation test. This paper presents a case of a patient with LAR and underlying house dust mite allergy, who was ultimately diagnosed >10 years after the onset of his first symptoms. Currently, there are only pharmacological treatments available for LAR. However, some studies show encouraging results with the use of allergen-specific immunotherapy in LAR, which offer hope for a future use of this causative treatment in LAR patients. Int J Occup Med Environ Health. 2020;33(2):241-6.

Keywords: dermatophagoides farinae; dermatophagoides pteronyssinus; entopy; local allergic rhinitis; nasal mucosa; nasal provocation test.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Allergens / adverse effects*
  • Antigens, Dermatophagoides / adverse effects*
  • Delayed Diagnosis
  • Diagnosis, Differential
  • Humans
  • Immunoglobulin E / blood
  • Male
  • Nasal Provocation Tests*
  • Phenotype*
  • Rhinitis, Allergic / diagnosis*
  • Skin Tests

Substances

  • Allergens
  • Antigens, Dermatophagoides
  • Immunoglobulin E