The immunopathogenesis of tuberculous pericarditis

Patrick Howlett; Elsa Du Bruyn; Hazel Morrison; Isiguzo C Godsent; Katalin A Wilkinson; Mpiko Ntsekhe; Robert J Wilkinson

doi:10.1016/j.micinf.2020.02.001

The immunopathogenesis of tuberculous pericarditis

Microbes Infect. 2020 May-Jun;22(4-5):172-181. doi: 10.1016/j.micinf.2020.02.001. Epub 2020 Feb 21.

Authors

Patrick Howlett¹, Elsa Du Bruyn², Hazel Morrison³, Isiguzo C Godsent⁴, Katalin A Wilkinson⁵, Mpiko Ntsekhe², Robert J Wilkinson⁶

Affiliations

¹ National Heart & Lung Institute, Imperial College London, Guy Scadding Building, Cale Street, London, SW3 6LY, United Kingdom; Department of Medicine, University of Cape Town, Observatory 7925, South Africa. Electronic address: [email protected].
² Department of Medicine, University of Cape Town, Observatory 7925, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.
³ The Jenner Institute, University of Oxford, Old Road Campus Research Build, Roosevelt Dr, Oxford OX3 7DQ, United Kingdom.
⁴ National Heart & Lung Institute, Imperial College London, Guy Scadding Building, Cale Street, London, SW3 6LY, United Kingdom; Department of Medicine, Federal Teaching Hospital Abakaliki, Nigeria.
⁵ Department of Medicine, University of Cape Town, Observatory 7925, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa; Francis Crick Institute, 1 Midland Rd, London NW1 1AT, United Kingdom.
⁶ Department of Medicine, University of Cape Town, Observatory 7925, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa; Francis Crick Institute, 1 Midland Rd, London NW1 1AT, United Kingdom; Department of Infectious Diseases, Imperial College London, W2 1PG, United Kingdom.

PMID: 32092538
DOI: 10.1016/j.micinf.2020.02.001

Abstract

Tuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8 and 34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in the histology, microbiology and immunology of tuberculous pericarditis, with special focus on the effect of Human Immunodeficiency Virus (HIV) and the determinants of constriction.

Keywords: Constriction; HIV; Immunology; Pathogenesis; Pericardial; Tuberculosis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

AIDS-Related Opportunistic Infections / immunology*
AIDS-Related Opportunistic Infections / microbiology
AIDS-Related Opportunistic Infections / pathology*
AIDS-Related Opportunistic Infections / therapy
Humans
Models, Immunological
Mycobacterium tuberculosis / immunology
Mycobacterium tuberculosis / pathogenicity
Pericardial Effusion / immunology
Pericardial Effusion / therapy
Pericarditis, Constrictive / immunology
Pericarditis, Constrictive / therapy
Pericarditis, Tuberculous / immunology*
Pericarditis, Tuberculous / microbiology
Pericarditis, Tuberculous / pathology*
Pericarditis, Tuberculous / therapy
T-Lymphocytes / immunology

Abstract

Publication types

MeSH terms

Grants and funding