Prophylaxis and treatment in liver transplantation. VII Consensus Document of the Spanish Society of Liver Transplantation

Gastroenterol Hepatol. 2020 Mar;43(3):169-177. doi: 10.1016/j.gastrohep.2019.11.005. Epub 2020 Feb 21.
[Article in English, Spanish]

Abstract

Whilst prophylaxis of hepatitis B is universally accepted after liver transplantation (LT), national recommendations for the prophylaxis and treatment of hepatitis B virus (HBV) infection after LT are lacking in Spain. The aim of the VII consensus meeting organised by the Spanish Society of Liver Transplantation (SETH) was to set recommendations on the prophylaxis and treatment of hepatitis B after LT. The scientific evidence and strength of recommendations was evaluated by using the "Grading of Recommendations Assessment, Development and Evaluation" (GRADE) system. This document describes the recommendations and their level of evidence for: the definition and risk factors for hepatitis B recurrence after LT, monitoring and prophylaxis of hepatitis B recurrence at different periods after LT, treatment of hepatitis B before and after LT, and the prophylaxis of HBV infection by the recipients of LT with hepatitis B core antigen positive donors.

Keywords: Análogos nucleósidos; Core positive grafts; Donante anticore; Donor-derived infection; Immunoglobulin; Infección adquirida; Inmunoglobulina específica; Nucleotides; Vaccination; Vacuna.

Publication types

  • Consensus Development Conference
  • Practice Guideline

MeSH terms

  • Alanine Transaminase / blood
  • Antiviral Agents / therapeutic use*
  • Combined Modality Therapy
  • DNA, Viral / blood
  • Drug Resistance, Multiple, Viral
  • Hepatitis B Antibodies / blood
  • Hepatitis B Antibodies / therapeutic use
  • Hepatitis B Core Antigens / immunology
  • Hepatitis B Surface Antigens / blood
  • Hepatitis B Vaccines / therapeutic use
  • Hepatitis B virus / drug effects
  • Hepatitis B virus / isolation & purification
  • Hepatitis B, Chronic / blood
  • Hepatitis B, Chronic / prevention & control*
  • Hepatitis B, Chronic / surgery
  • Humans
  • Liver Transplantation / methods*
  • Preoperative Care / methods*
  • Recurrence
  • Risk Factors
  • Tissue Donors
  • Vaccination
  • Viral Load
  • Viremia / blood

Substances

  • Antiviral Agents
  • DNA, Viral
  • Hepatitis B Antibodies
  • Hepatitis B Core Antigens
  • Hepatitis B Surface Antigens
  • Hepatitis B Vaccines
  • Alanine Transaminase