Oral administration of protein nanoparticles: An emerging route to disease treatment

Samira Sadeghi; Wai Kit Lee; Shik Nie Kong; Annanya Shetty; Chester Lee Drum

doi:10.1016/j.phrs.2020.104685

Oral administration of protein nanoparticles: An emerging route to disease treatment

Pharmacol Res. 2020 Aug:158:104685. doi: 10.1016/j.phrs.2020.104685. Epub 2020 Feb 22.

Authors

Samira Sadeghi¹, Wai Kit Lee², Shik Nie Kong³, Annanya Shetty³, Chester Lee Drum⁴

Affiliations

¹ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore; Translational Laboratory in Genetic Medicine, 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore.
² Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, 3800, Australia.
³ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
⁴ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore; Translational Laboratory in Genetic Medicine, 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore; Cardiovascular Research Institute, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 9, NUHCS, Singapore, 119228, Singapore; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. Electronic address: [email protected].

PMID: 32097749
DOI: 10.1016/j.phrs.2020.104685

Abstract

Over the last two decades, developments in nanomedicine have resulted in technical advances with application to clinical science. Both organic and inorganic nanoparticles (NPs) have shown tolerability, pharmacologic specificity and biodegradability. A subclass of NPs, protein NPs, have garnered recent attention due to the inherent biocompatibility of protein substrates. Protein NPs are currently being employed widely in pharmaceuticals development with applications in nasal, pulmonary, intravenous, ocular and oral delivery. Despite the distinct advantages of orally administered pharmaceuticals, the development of oral delivery systems has been comparatively limited. Therefore, this review attempts to discuss the most recent experimental and pre-clinical findings in the development of protein NPs for oral delivery, while envisioning upcoming challenges.

Keywords: Gastrointestinal tract; Nanoparticle; Oral delivery; Targeted therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Administration, Oral
Animals
Drug Delivery Systems
Drug Therapy / trends*
Humans
Nanomedicine
Nanoparticles*
Proteins / administration & dosage*
Proteins / therapeutic use*

Substances

Proteins