Abstract
The efficiency and toxicity of E. coli-L-Asparaginase coupled to polyethyleneglycol (PEG-ASP) was investigated in 5 patients with second relapse of acute lymphoblastic leukemia. PEG-ASP was administered at a dose of 2000 U/m2 as infusion over 2 hrs. every 2 weeks. Following an initial single agent phase, PEG-ASP was combined with prednisone, vincristine, adriamycin and methotrexate i.t. Following induction, all 5 patients were in third remission. The remissions lasted from 3 to 9 months, median 4 months. The toxicity was transient and mild. Also in patients sensitized against native L-Asparaginase no anaphylactic reactions were observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Asparaginase / adverse effects
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Asparaginase / therapeutic use*
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Child
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Child, Preschool
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Doxorubicin / administration & dosage
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Drug Administration Schedule
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Drug Evaluation
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Female
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Follow-Up Studies
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Humans
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Leukemia, Lymphoid / drug therapy*
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Leukocyte Count / drug effects
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Male
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Methotrexate / administration & dosage
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Polyethylene Glycols / adverse effects
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Polyethylene Glycols / therapeutic use*
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Prednisone / administration & dosage
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Vincristine / administration & dosage
Substances
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Polyethylene Glycols
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Vincristine
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pegaspargase
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Doxorubicin
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Asparaginase
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Prednisone
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Methotrexate