rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer's disease patients compared with controls

Guiyou Liu; Haihua Zhang; Bian Liu; Tao Wang; Zhifa Han; Xunming Ji

doi:10.1007/s00401-020-02135-9

rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer's disease patients compared with controls

Acta Neuropathol. 2020 May;139(5):937-940. doi: 10.1007/s00401-020-02135-9. Epub 2020 Feb 29.

Authors

Guiyou Liu^{1

2

3}, Haihua Zhang^{4

5}, Bian Liu^{6

5}, Tao Wang^{7

8}, Zhifa Han^{9

10

11}, Xunming Ji^{12

13

14

15}

Affiliations

¹ Department of Neurology, Xuanwu Hospital, Capital Medical University, Room 1037, Donghuajinzuo, Guanganmennei Street, XiCheng District, Beijing, 100053, China. [email protected].
² Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. [email protected].
³ National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. [email protected].
⁴ Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China.
⁵ National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
⁶ Department of Neurology, Xuanwu Hospital, Capital Medical University, Room 1037, Donghuajinzuo, Guanganmennei Street, XiCheng District, Beijing, 100053, China.
⁷ Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
⁸ Chinese Institute for Brain Research, Beijing, China.
⁹ School of Medicine, School of Pharmaceutical Sciences, THU-PKU Center for Life Sciences, Tsinghua University, Beijing, China.
¹⁰ State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China.
¹¹ Department of Pathophysiology, Peking Union Medical College, Beijing, China.
¹² Department of Neurology, Xuanwu Hospital, Capital Medical University, Room 1037, Donghuajinzuo, Guanganmennei Street, XiCheng District, Beijing, 100053, China. [email protected].
¹³ Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. [email protected].
¹⁴ National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. [email protected].
¹⁵ Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. [email protected].

PMID: 32112171
DOI: 10.1007/s00401-020-02135-9

No abstract available

Keywords: ABCA7; Alzheimer’s disease; Gene expression; eQTLs analysis; rs4147929 variant.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

ATP-Binding Cassette Transporters / genetics*
Alleles
Alzheimer Disease / genetics*
Gene Expression / genetics*
Genetic Association Studies
Genetic Predisposition to Disease / genetics*
Humans

Substances

ABCA7 protein, human
ATP-Binding Cassette Transporters

Publication types

MeSH terms

Substances

Grants and funding