Stimuli-Responsive Delivery of Growth Factors for Tissue Engineering

Moyuan Qu; Xing Jiang; Xingwu Zhou; Canran Wang; Qingzhi Wu; Li Ren; Jixiang Zhu; Songsong Zhu; Peyton Tebon; Wujin Sun; Ali Khademhosseini

doi:10.1002/adhm.201901714

Stimuli-Responsive Delivery of Growth Factors for Tissue Engineering

Adv Healthc Mater. 2020 Apr;9(7):e1901714. doi: 10.1002/adhm.201901714. Epub 2020 Mar 3.

Authors

Moyuan Qu^{1

2}, Xing Jiang^{1

3}, Xingwu Zhou^{1

4}, Canran Wang^{1

5}, Qingzhi Wu^{1

6}, Li Ren^{1

7}, Jixiang Zhu^{1

8}, Songsong Zhu², Peyton Tebon¹, Wujin Sun¹, Ali Khademhosseini^{1

4

9}

Affiliations

¹ Department of Bioengineering, California NanoSystems Institute and Center for Minimally Invasive Therapeutics (C-MIT) University of California, Los Angeles, Los Angeles, CA, 90095, USA.
² State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
³ School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
⁴ Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
⁵ Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
⁶ State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China.
⁷ School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China.
⁸ Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
⁹ Jonsson Comprehensive Cancer Center, Department of Radiology University of California-Los Angeles, Los Angeles, CA, 90095, USA.

Abstract

Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half-life within the physiological microenvironment and significant side effects caused by off-target effects or improper dosage. "Smart" materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on-demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these "smart" materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease-specific stimuli. The aim of this review is to summarize the current research on stimuli-responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such "smart" materials and perspectives on future applications of stimuli-responsive GF delivery for tissue regeneration are also discussed.

Keywords: growth factors; regenerative medicine; stimuli-responsive delivery; tissue engineering.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Drug Delivery Systems*
Intercellular Signaling Peptides and Proteins
Tissue Engineering*
Wound Healing

Substances

Intercellular Signaling Peptides and Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding