Abstract
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Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology.
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The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses.
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The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region.
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Integrin binding may be a promising therapeutics target, and should be tested experimentally.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Betacoronavirus / metabolism*
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COVID-19
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Coronavirus Infections / physiopathology*
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Coronavirus Infections / virology
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Drug Delivery Systems
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Host-Pathogen Interactions / physiology*
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Humans
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Integrins / metabolism*
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Pandemics
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Pneumonia, Viral / physiopathology*
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Pneumonia, Viral / virology
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Protein Binding
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Protein Interaction Domains and Motifs
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SARS-CoV-2
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Spike Glycoprotein, Coronavirus / chemistry
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Spike Glycoprotein, Coronavirus / metabolism
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Virus Internalization*
Substances
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Integrins
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Spike Glycoprotein, Coronavirus
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spike protein, SARS-CoV-2