Chemotherapy Induces Cancer-Fighting B Cells

Zhida Liu; Yang-Xin Fu

doi:10.1016/j.cell.2020.02.046

Chemotherapy Induces Cancer-Fighting B Cells

Cell. 2020 Mar 19;180(6):1037-1039. doi: 10.1016/j.cell.2020.02.046. Epub 2020 Mar 5.

Authors

Zhida Liu¹, Yang-Xin Fu²

Affiliations

¹ Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
² Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. Electronic address: [email protected].

PMID: 32142652
DOI: 10.1016/j.cell.2020.02.046

Abstract

Tumor-infiltrating B cells are heterogeneous, and their roles in tumor immunity are controversial. In this issue of Cell, Lu and colleagues demonstrate that chemotherapy-induced complement signals promote the generation of ICOSL⁺B cells, which enhance tumor-specific T cell responses.

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MeSH terms

Antineoplastic Agents*
B-Lymphocytes
Humans
Neoplasms*
T-Lymphocytes

Substances

Antineoplastic Agents