Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells

Tiago C Luis; Hannah Lawson; Kamil R Kranc

doi:10.1016/j.stem.2020.02.009

Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells

Cell Stem Cell. 2020 Mar 5;26(3):299-301. doi: 10.1016/j.stem.2020.02.009.

Authors

Tiago C Luis¹, Hannah Lawson², Kamil R Kranc³

Affiliations

¹ Haematopoietic Stem Cell Niche Laboratory, Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK. Electronic address: [email protected].
² Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
³ Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. Electronic address: [email protected].

PMID: 32142657
DOI: 10.1016/j.stem.2020.02.009

Abstract

Hematopoietic stem cells (HSCs) remain quiescent to preserve long-term integrity. In this issue of Cell Stem Cell, Hinge et al. (2020) and Liang et al. (2020) demonstrate that HSCs achieve this by regulating mitochondrial fission and lysosomal activity, suppressing glucose uptake, and maintaining healthy punctate mitochondria with low metabolic activity.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Division
Cell Self Renewal
Hematopoietic Stem Cells*
Mitochondria
Mitochondrial Dynamics*

Abstract

Publication types

MeSH terms

Grants and funding