A comparison of GAD- and GABA-immunoreactive neurons in the first somatosensory area (SI) of the rat cortex

R Spreafico; S De Biasi; C Frassoni; G Battaglia

doi:10.1016/0006-8993(88)90684-1

A comparison of GAD- and GABA-immunoreactive neurons in the first somatosensory area (SI) of the rat cortex

Brain Res. 1988 Nov 22;474(1):192-6. doi: 10.1016/0006-8993(88)90684-1.

Authors

R Spreafico¹, S De Biasi, C Frassoni, G Battaglia

Affiliation

¹ Department of Neurophysiology, Istituto Neurologico C. Besta, Milan, Italy.

PMID: 3214713
DOI: 10.1016/0006-8993(88)90684-1

Abstract

Neurons immunoreactive for anti-glutamic acid decarboxylase (anti-GAD) and anti-gamma-aminobutyric acid (anti-GABA) were compared in adjacent sections from the rat somatosensory cortex (SI). GAD- and GABA-positive neurons in animals either treated or not treated with colchicine were found to occur at a ratio of 1:2. Measurement of areas of GAD- and GABA-immunoreactive neurons confirmed the presence of an 'exuberant' GABA-positive neuronal population not visualized by the GAD antiserum.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Count
Glutamate Decarboxylase / metabolism*
Immunohistochemistry
Rats
Somatosensory Cortex / cytology
Somatosensory Cortex / metabolism*
gamma-Aminobutyric Acid / metabolism*

Substances

gamma-Aminobutyric Acid
Glutamate Decarboxylase