Recent advances in iNKT cell development

F1000Res. 2020 Feb 20:9:F1000 Faculty Rev-127. doi: 10.12688/f1000research.21378.1. eCollection 2020.

Abstract

Recent studies suggest that murine invariant natural killer T (iNKT) cell development culminates in three terminally differentiated iNKT cell subsets denoted as NKT1, 2, and 17 cells. Although these studies corroborate the significance of the subset division model, less is known about the factors driving subset commitment in iNKT cell progenitors. In this review, we discuss the latest findings in iNKT cell development, focusing in particular on how T-cell receptor signal strength steers iNKT cell progenitors toward specific subsets and how early progenitor cells can be identified. In addition, we will discuss the essential factors for their sustenance and functionality. A picture is emerging wherein the majority of thymic iNKT cells are mature effector cells retained in the organ rather than developing precursors.

Keywords: CD1d; T cell receptor signalling; agonist selection; development; invariant natural killer T cells; lipid; subsets; thymus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Lymphocyte Subsets / cytology
  • Mice
  • Natural Killer T-Cells / cytology*
  • Receptors, Antigen, T-Cell
  • Thymus Gland / cytology

Substances

  • Receptors, Antigen, T-Cell