Using laser treatments and calcium and phosphate compounds to enhance remineralization has been investigated in this study. Seventy two premolar teeth were divided into four groups of 18: 1) control group; 2) laser therapy group; 3) CPP-ACP paste group; and 4) laser therapy and CPP-ACP group. Mineralization and remineralization of samples were investigated by Diagnodent. Data were reported using descriptive statistics (mean, standard deviation) and One Way ANOVA; they were analyzed using SPSS.16 statistical software. Statistical analysis showed that groups 3 and 4 had the highest rate of remineralization compared to groups 1 and 2. According to the results of this study, mineralization ranged decreasingly from group 4 to groups 3, 2, and 1, respectively. The antibacterial effect of laser therapy, leading to remineralization of calcium and phosphorus compounds, was the most effective on controlling root decay.