Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum

Nat Prod Res. 2021 Nov;35(22):4534-4541. doi: 10.1080/14786419.2020.1739044. Epub 2020 Mar 12.

Abstract

Descaudatine A (1), an undescribed phenolic glycoside, along with a known analogue (2) and ten flavonoids (3-12), were isolated from the whole plant of Desmodium caudatum. Compounds 1 and 4 exhibited potent antioxidant activities with the IC50 of 58.59 μM and 31.31 μM, respectively, which were approached to that of the positive control Vitamin C (IC50 = 46.32 μM). Meanwhile, 12 showed moderate antioxidant activity with the IC50 of 173.9 μM. Besides, compounds 3 and 6 inhibited the proliferation of HeLa cells with IC50 values of 56.14 μM and 69.04 μM, respectively. Further studies indicated that 3 and 6 could dose-dependently induce PARP cleavage and might trigger caspase-3, 8, 9 activation to induce apoptosis. RXRα is an ideal anticancer target of nuclear receptor. The reporter gene assay of RXRα indicated that 3 and 6 could inhibited the 9-cis-RA induced RXRα transcription in a concentration-dependent manner.

Keywords: Desmodium caudatum; anticancer; antioxidant; flavonoids; phenolic glycoside.

MeSH terms

  • Antioxidants* / pharmacology
  • Flavonoids* / pharmacology
  • Glycosides / pharmacology
  • HeLa Cells
  • Humans
  • Phenols / pharmacology
  • Plant Extracts / pharmacology

Substances

  • Antioxidants
  • Flavonoids
  • Glycosides
  • Phenols
  • Plant Extracts