Cold-Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity

Objective: This study aimed to test the hypothesis that young adults with obesity and cold-activated brown adipose tissue (BAT) are less likely to have metabolic dysfunction (dyslipidemia, insulin resistance, and hypertension) than those without cold-activated BAT. Previous studies have noted a potentially protective effect of BAT and higher adiponectin/leptin ratios, but they have acknowledged that the clinical implications of these findings remain uncertain.

Methods: Twenty-one females and twenty-three males with obesity (BMI ≥ 30 kg/m² ) underwent a 2-hour cooling protocol before ¹⁸ F-fluorodeoxyglucose (¹⁸ F-FDG)-positron emission tomography/x-ray computed tomography scan to determine the prevalence, volume, and ¹⁸ F-FDG uptake of cold-activated BAT.

Results: Cold-activated BAT was identified in 43% of participants (11 female, 8 male); females had greater ¹⁸ F-FDG uptake. Those with cold-activated BAT had a lesser degree of metabolic dysfunction. Cold-activated BAT volume correlated with triglycerides (inversely) and adiponectin (concordantly). Body-mass-adjusted cold-activated BAT activity correlated with high-density lipoprotein cholesterol (concordantly). Males with cold-activated BAT had lower leptin and higher adiponectin/leptin ratio.

Conclusions: A high prevalence of cold-activated BAT was found in the study participants. BAT could be important in decreasing metabolic dysfunction among young adults with obesity, making it a potential target for treating metabolically unhealthy obesity.