Circadian and sleep dysfunction in Alzheimer's disease

Md Sahab Uddin; Devesh Tewari; Abdullah Al Mamun; Md Tanvir Kabir; Kamal Niaz; Mir Imam Ibne Wahed; George E Barreto; Ghulam Md Ashraf

doi:10.1016/j.arr.2020.101046

Circadian and sleep dysfunction in Alzheimer's disease

Ageing Res Rev. 2020 Jul:60:101046. doi: 10.1016/j.arr.2020.101046. Epub 2020 Apr 16.

Authors

Md Sahab Uddin¹, Devesh Tewari², Abdullah Al Mamun³, Md Tanvir Kabir⁴, Kamal Niaz⁵, Mir Imam Ibne Wahed⁶, George E Barreto⁷, Ghulam Md Ashraf⁸

Affiliations

¹ Department of Pharmacy, Southeast University, Dhaka, Bangladesh; Pharmakon Neuroscience Research Network, Dhaka, Bangladesh. Electronic address: [email protected].
² Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
³ Department of Pharmacy, Southeast University, Dhaka, Bangladesh; Pharmakon Neuroscience Research Network, Dhaka, Bangladesh.
⁴ Department of Pharmacy, BRAC University, Dhaka, Bangladesh.
⁵ Department of Pharmacology and Toxicology, Faculty of Bioscience and Agri-Food and Environmental Technology, University of Teramo, 64100, Italy.
⁶ Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh.
⁷ Department of Biological Sciences, University of Limerick, Limerick, Ireland; Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile. Electronic address: [email protected].
⁸ King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: [email protected].

PMID: 32171783
DOI: 10.1016/j.arr.2020.101046

Abstract

Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the most common type of dementia. Along with progressive cognitive impairment, dysfunction of the circadian rhythms also plays a pivotal role in the progression of AD. A mutual relationship among circadian rhythms, sleep, and AD has been well-recommended. The etiopathogenesis of the disturbances of the circadian system and AD share some general features that also unlock the outlook of observing them as a mutually dependent pathway. Indeed, the burden of amyloid β (Aβ), neurofibrillary tangles (NFTs), neuroinflammation, oxidative stress, and dysfunction of circadian rhythms may lead to AD. Aging can alter both sleep timings and quality that can be strongly disrupted in AD. Increased production of Aβ and reduced Aβ clearance are caused by a close interplay of Aβ, sleep disturbance and raised wakefulness. Besides Aβ, the impact of tau pathology is possibly noteworthy to the sleep deprivation found in AD. Hence, this review is focused on the primary mechanistic complexities linked to disruption of circadian rhythms, sleep deprivation, and AD. Furthermore, this review also highlights the potential therapeutic strategies to abate AD pathogenesis.

Keywords: Alzheimer's disease; Amyloid β; Circadian rhythms; Neurofibrillary tangles; Sleep.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging
Alzheimer Disease* / complications
Alzheimer Disease* / physiopathology
Amyloid beta-Peptides
Humans
Neurofibrillary Tangles
Sleep Wake Disorders* / complications

Substances

Amyloid beta-Peptides