Risk factors of the efficacy of hepatitis B vaccine in health-care workers

Hassan Salehi; Marzieh Salehi; Nader Kalbasi; Maryam Salehi; Jalil Sharifian; Mohammad Mahdi Salehi

doi:10.4103/jrms.JRMS_1054_18

Risk factors of the efficacy of hepatitis B vaccine in health-care workers

J Res Med Sci. 2020 Feb 20:25:15. doi: 10.4103/jrms.JRMS_1054_18. eCollection 2020.

Authors

Hassan Salehi¹, Marzieh Salehi², Nader Kalbasi³, Maryam Salehi⁴, Jalil Sharifian⁵, Mohammad Mahdi Salehi⁴

Affiliations

¹ Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
² Department of Infectious Diseases, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Department of Oral and Facial Pathology, Dentistry Faculty, Khoraskan University, Isfahan, Iran.
⁴ Dentistry Student Research Center, Dentistry School, Isfahan University of Medical Sciences, Isfahan, Iran.
⁵ Oral Surgery Department, Dentistry School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Background: Conventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%-10% of the world population. Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health-care workers.

Materials and methods: This was a descriptive study which was implemented among 140 of medical and dental staff working as health-care workers who were low responder after vaccination entered the study.

Results: Age (>40 years), weight (body mass index >25), immunodeficiency diseases, (primary immune deficiency and immunosuppressant drugs), diabetes mellitus, and smoking were the important factors.

Conclusion: In the high-risk group of hepatitis B disease, the risk factors of immunogenicity must be evaluated at vaccination and check titers of antibody after vaccination.

Keywords: Health-care workers; hepatitis B; vaccine efficacy.