An evolutionary framework for treating pediatric sarcomas

Damon R Reed; Jonathan Metts; Mariyah Pressley; Brooke L Fridley; Masanori Hayashi; Michael S Isakoff; David M Loeb; Rikesh Makanji; Ryan D Roberts; Matteo Trucco; Lars M Wagner; Mark G Alexandrow; Robert A Gatenby; Joel S Brown

doi:10.1002/cncr.32777

An evolutionary framework for treating pediatric sarcomas

Cancer. 2020 Jun 1;126(11):2577-2587. doi: 10.1002/cncr.32777. Epub 2020 Mar 16.

Authors

Damon R Reed^{1

2

3}, Jonathan Metts⁴, Mariyah Pressley^{2

5}, Brooke L Fridley^{2

6}, Masanori Hayashi⁷, Michael S Isakoff⁸, David M Loeb⁹, Rikesh Makanji¹⁰, Ryan D Roberts¹¹, Matteo Trucco¹², Lars M Wagner¹³, Mark G Alexandrow², Robert A Gatenby^{2

5

10}, Joel S Brown^{2

5}

Affiliations

¹ Department of Interdisciplinary Cancer Management, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
² Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
³ Adolescent and Young Adult Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
⁴ Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St Petersburg, Florida.
⁵ Integrative Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
⁶ Biostatistics and Bioinformatics Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
⁷ Department of Pediatrics, University of Colorado Denver, Aurora, Colorado.
⁸ Center for Cancer and Blood Disorders, Connecticut Children's Medical Center, Hartford, Connecticut.
⁹ Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
¹⁰ Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
¹¹ Department of Pediatric Hematology, Oncology, and Bone Marrow Transplantation, Nationwide Children's Hospital, Columbus, Ohio.
¹² Depatment of Pediatrics, University of Miami, Miami, Florida.
¹³ Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.

Abstract

Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.

Keywords: Ewing sarcoma; adaptive therapy; clinical trial; evolution; extinction therapy; first strike; osteosarcoma; resistance; rhabdomyosarcoma; second strike.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biological Evolution
Bone Neoplasms / therapy
Child
Clinical Trials as Topic
Humans
Models, Theoretical
Osteosarcoma / therapy
Rhabdomyosarcoma / therapy
Sarcoma / genetics
Sarcoma / therapy*
Sarcoma, Ewing / therapy
Selection, Genetic

Abstract

Publication types

MeSH terms

Grants and funding