Extended half-life rFIX in major surgery-How to improve clinical practice: An intraindividual comparison

Federica Valeri; Jacopo Agnelli Giacchello; Cristina Dainese; Alessandra Valpreda; Barbara Montaruli; Enrico Dosio; Mario Boccadoro; Alessandra Borchiellini

doi:10.1002/ccr3.2450

Extended half-life rFIX in major surgery-How to improve clinical practice: An intraindividual comparison

Clin Case Rep. 2020 Feb 12;8(3):531-534. doi: 10.1002/ccr3.2450. eCollection 2020 Mar.

Authors

Federica Valeri¹, Jacopo Agnelli Giacchello¹, Cristina Dainese¹, Alessandra Valpreda², Barbara Montaruli³, Enrico Dosio², Mario Boccadoro¹, Alessandra Borchiellini¹

Affiliations

¹ Haematology Unit Regional Center for Hemorrhagic and Thrombotic Diseases City of Health and Science University Hospital of Molinette Turin Italy.
² Regional Center for Hemorrhagic and Thrombotic Diseases Haematology Laboratory City of Health and Science University Hospital of Molinette Turin Italy.
³ Hematological Laboratoy Mauriziano Hospital Turin Italy.

Abstract

Practical, safe, and effective hemostatic approach to orthopedic surgery using Extended Half-Life factor IX in hemophilia B. By intraindividual comparison, we found a lower FIX consumption, number of infusions, and cost compared to plasma-derived FIX.

Keywords: extended half‐life FIX; hemophilia B; major surgery; orthopedic; pharmacokinetic; real‐life experience.

Publication types

Case Reports