An Inbred Ecosystem that Supports Medulloblastoma

Immunity. 2020 Mar 17;52(3):431-433. doi: 10.1016/j.immuni.2020.02.010.

Abstract

In a recent issue of Cell, Yao et al. use a unique genetic strategy to study sonic hedgehog-medulloblastoma. Their results reveal a complex network in the tumor microenvironment involving the trans-differentiation of cancer cells into astrocytes to fuel tumor growth.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Transdifferentiation
  • Cerebellar Neoplasms*
  • Ecosystem
  • Hedgehog Proteins
  • Humans
  • Medulloblastoma*
  • Tumor Microenvironment

Substances

  • Hedgehog Proteins