Transmission of COVID-19 in the terminal stages of the incubation period: A familial cluster

Peng Li; Ji-Bo Fu; Ke-Feng Li; Jie-Nan Liu; Hong-Ling Wang; Lei-Jie Liu; Yan Chen; Yong-Li Zhang; She-Lan Liu; An Tang; Zhen-Dong Tong; Jian-Bo Yan

doi:10.1016/j.ijid.2020.03.027

Transmission of COVID-19 in the terminal stages of the incubation period: A familial cluster

Int J Infect Dis. 2020 Jul:96:452-453. doi: 10.1016/j.ijid.2020.03.027. Epub 2020 Mar 16.

Authors

Peng Li¹, Ji-Bo Fu², Ke-Feng Li³, Jie-Nan Liu⁴, Hong-Ling Wang⁵, Lei-Jie Liu⁶, Yan Chen⁷, Yong-Li Zhang⁸, She-Lan Liu⁹, An Tang¹⁰, Zhen-Dong Tong¹¹, Jian-Bo Yan¹²

Affiliations

¹ Zhoushan Center for Disease Control and Prevention, No. 568, Wengshan Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
² Putuo Center for Disease Control and Prevention, No. 111, Food Factory Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
³ Zhoushan Center for Disease Control and Prevention, No. 568, Wengshan Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
⁴ Zhoushan Center for Disease Control and Prevention, No. 568, Wengshan Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
⁵ Zhoushan Center for Disease Control and Prevention, No. 568, Wengshan Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
⁶ Putuo Center for Disease Control and Prevention, No. 111, Food Factory Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
⁷ Zhoushan Center for Disease Control and Prevention, No. 568, Wengshan Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
⁸ Putuo Center for Disease Control and Prevention, No. 111, Food Factory Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
⁹ Zhejiang Provincial Center for Disease Control and Prevention, No. 3399 Binsheng Rd, 320051, Hangzhou City, Zhejiang Province, China. Electronic address: [email protected].
¹⁰ Zhoushan Center for Disease Control and Prevention, No. 568, Wengshan Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
¹¹ Zhoushan Center for Disease Control and Prevention, No. 568, Wengshan Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].
¹² Zhoushan Center for Disease Control and Prevention, No. 568, Wengshan Rd, 316021, Zhoushan City, Zhejiang Province, China. Electronic address: [email protected].

Abstract

We report a familial cluster of 2019 novel coronavirus disease (COVID-19) to assess its potential transmission during the incubation period. The first patient in this familial cluster was identified during the presymptomatic period, as a close contact of a confirmed patient. Five family members had close contact with this first patient during his incubation period, with four of them confirmed positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the subsequent sampling tests.

Keywords: COVID-19; Cluster; Incubation period; SARS-CoV-2.

MeSH terms

Adult
Aged
Betacoronavirus*
COVID-19
Child
Coronavirus Infections / transmission*
Family
Female
Humans
Infectious Disease Incubation Period*
Male
Middle Aged
Pandemics
Pneumonia, Viral / transmission*
SARS-CoV-2