SnapShot: Natural Killer Cells

Adeline Crinier; Emilie Narni-Mancinelli; Sophie Ugolini; Eric Vivier

doi:10.1016/j.cell.2020.02.029

SnapShot: Natural Killer Cells

Cell. 2020 Mar 19;180(6):1280-1280.e1. doi: 10.1016/j.cell.2020.02.029.

Authors

Adeline Crinier¹, Emilie Narni-Mancinelli¹, Sophie Ugolini¹, Eric Vivier²

Affiliations

¹ Aix Marseille Univ, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
² Aix Marseille Univ, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France; Immunology, Marseille Immunopole, Hôpital de la Timone, Assistance Publique des Hôpitaux de Marseille, France; Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.

PMID: 32200803
DOI: 10.1016/j.cell.2020.02.029

Abstract

NK cells are broadly distributed innate lymphoid cells (ILCs) encompassing distinct populations based on CD11b and CD27 expression in mice or CD56 intensity in humans. Involved in anti-viral and anti-tumor immunity thanks to their cytokines and chemokines secretion as well as their cytotoxic capabilities, NK cells have emerged as a promising therapeutic target in several solid tumors and hematological malignancies. To view this Snapshot, open or download the PDF.

MeSH terms

Animals
Cytokines / metabolism
Humans
Immunity, Innate
Immunotherapy, Active / methods
Killer Cells, Natural / immunology*
Killer Cells, Natural / metabolism*
Killer Cells, Natural / physiology*
Mice
Neoplasms / immunology

Substances

Cytokines