Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions

Oxana Semyachkina-Glushkovskaya; Arkady Abdurashitov; Alexander Dubrovsky; Maria Klimova; Ilana Agranovich; Andrey Terskov; Alexander Shirokov; Valeria Vinnik; Anna Kuzmina; Nikita Lezhnev; Inna Blokhina; Anastassia Shnitenkova; Valery Tuchin; Edik Rafailov; Jurgen Kurths

doi:10.1364/BOE.383390

Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions

Biomed Opt Express. 2020 Jan 10;11(2):725-734. doi: 10.1364/BOE.383390. eCollection 2020 Feb 1.

Authors

Oxana Semyachkina-Glushkovskaya¹, Arkady Abdurashitov^{1

2}, Alexander Dubrovsky¹, Maria Klimova¹, Ilana Agranovich¹, Andrey Terskov¹, Alexander Shirokov^{1

3}, Valeria Vinnik¹, Anna Kuzmina¹, Nikita Lezhnev¹, Inna Blokhina¹, Anastassia Shnitenkova¹, Valery Tuchin^{1

2

4}, Edik Rafailov^{1

5}, Jurgen Kurths^{1

6

7}

Affiliations

¹ Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
² Tomsk State University, 36 Lenin's Ave., Tomsk 634050, Russian Federation, Russia.
³ Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Entusiastov Str. 13, Saratov 410049, Russia.
⁴ Institute of Precision Mechanics and Control of the Russian Academy of Sciences, 24 Rabochaya Str., Saratov 410028, Russian Federation, Russia.
⁵ Optoelectronics and Biomedical Photonics Group, Aston University, Birmingham, B4 7ET, UK.
⁶ Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany Potsdam, Germany.
⁷ Institute for Climate Impact Research, Telegrafenberg A31, 14473 Potsdam, Germany.

Abstract

There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance. Our results obtained at optical coherence tomography (OCT) give strong evidence that low PBM doses (5 and 10 J/cm²) stimulate drainage function of the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying increasing the permeability of the lymphatic endothelium that allows molecules transported by the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These findings open new strategies for the stimulation of MLVs functions and non-pharmacological therapy of brain diseases.