How to maintain the genome in nuclear space

Ioanna Mitrentsi; Duygu Yilmaz; Evi Soutoglou

doi:10.1016/j.ceb.2020.02.014

How to maintain the genome in nuclear space

Curr Opin Cell Biol. 2020 Jun:64:58-66. doi: 10.1016/j.ceb.2020.02.014. Epub 2020 Mar 26.

Authors

Ioanna Mitrentsi¹, Duygu Yilmaz¹, Evi Soutoglou²

Affiliations

¹ Institut de Génétique et de Biologie Moléculaire et Celullaire, 67404, Illkirch, France; Institut National de La Santé et de La Recherche Médicale, U964, 67404, Illkirch, France; Centre National de Recherche Scientifique, UMR7104, 67404, Illkirch, France; Université de Strasbourg, 67081, Strasbourg, France.
² Institut de Génétique et de Biologie Moléculaire et Celullaire, 67404, Illkirch, France; Institut National de La Santé et de La Recherche Médicale, U964, 67404, Illkirch, France; Centre National de Recherche Scientifique, UMR7104, 67404, Illkirch, France; Université de Strasbourg, 67081, Strasbourg, France. Electronic address: [email protected].

PMID: 32220808
DOI: 10.1016/j.ceb.2020.02.014

Abstract

Genomic instability can be life-threatening. The fine balance between error-free and mutagenic DNA repair pathways is essential for maintaining genome integrity. Recent advances in DNA double-strand break induction and detection techniques have allowed the investigation of DNA damage and repair in the context of the highly complex nuclear structure. These studies have revealed that the 3D genome folding, nuclear compartmentalization and cytoskeletal components control the spatial distribution of DNA lesions within the nuclear space and dictate their mode of repair.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Nucleus / genetics*
DNA Damage
DNA Repair / genetics
Genome*
Genomic Instability
Humans
Transcription, Genetic