A young child with HIV and unsteady gait: A case report

Nadine Yazbeck; Yolla Youssef; Rima Hanna-Wakim

doi:10.1016/j.idcr.2019.e00643

A young child with HIV and unsteady gait: A case report

IDCases. 2019 Nov 2:19:e00643. doi: 10.1016/j.idcr.2019.e00643. eCollection 2020.

Authors

Nadine Yazbeck¹, Yolla Youssef^{1

2

3}, Rima Hanna-Wakim^{1

2

3}

Affiliations

¹ Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
² Division of Pediatric Infectious Diseases, Department of Pediatrics and Adolescent Medicine, Lebanon.
³ Center for Infectious Diseases Research, American University of Beirut Medical Center, Beirut, Lebanon.

Abstract

Background: We would like to raise awareness about the toxicities related to the added excipients present in the oral solution of Liponavir/ritonavir in particular alcohol and propylene glycol.

Case presentation: In this case report, we describe an 18 month-old child with a newly diagnosed HIV infection on antiretroviral therapy (ART). She developed shortly after starting the ART unsteady gait and imbalance.

Conclusions: The excipient-excipient interaction in Lopinavir/ritonavir may contribute to major toxicities not only in premature neonates and infants; but also in older children specifically from Asian ethnicity.

Keywords: 3TC, Lamivudine; ADH, alcohol dehydrogenase; ALDH, aldehyde dehydrogenase; ART, antiretroviral therapy; AZT, Zidovudine; CNS, central nervous system; HIV; LPV/r, Lopinavir/ritonavir; Lopinavir-ritonavir; PI, protease inhibitor; Unsteady gait; WHO, World Health Organization.

Publication types

Case Reports