Heart Failure with Preserved Ejection Fraction and Obesity: Syndrome of cGMP-PKG Deficiency in Post-Menopausal Women

Arjun Sinha; Clyde W Yancy; Sanjiv J Shah; Sadiya S Khan

doi:10.1016/j.jaccas.2019.11.065

Heart Failure with Preserved Ejection Fraction and Obesity: Syndrome of cGMP-PKG Deficiency in Post-Menopausal Women

JACC Case Rep. 2020 Jan;2(1):28-32. doi: 10.1016/j.jaccas.2019.11.065. Epub 2020 Jan 15.

Authors

Arjun Sinha^{1

2}, Clyde W Yancy², Sanjiv J Shah², Sadiya S Khan^{1

2}

Affiliations

¹ Department of Preventive Medicine, Northwestern University Feinberg School of Medicine.
² Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine.

Abstract

The authors report a case of heart failure with preserved ejection fraction in a post-menopausal woman with obesity. The case highlights a metabolic phenotype of heart failure with preserved ejection fraction that commonly presents in women with discussion focusing on the pathophysiology, mechanistic pathways, and potential targeted therapeutic strategies.

Keywords: HFpEF; obesity; women.

Abstract

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