Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges
CPT Pharmacometrics Syst Pharmacol
.
2020 Apr;9(4):195-197.
doi: 10.1002/psp4.12504.
Epub 2020 Apr 1.
Authors
Flora T Musuamba
1
2
3
,
Roberta Bursi
4
,
Efthymios Manolis
1
5
,
Kristin Karlsson
1
6
,
Alexander Kulesza
7
,
Eulalie Courcelles
7
,
Jean-Pierre Boissel
7
,
Raphaëlle Lesage
8
,
Cécile Crozatier
9
,
Emmanuelle M Voisin
9
,
Cécile F Rousseau
9
,
Thierry Marchal
10
,
Rossana Alessandrello
11
,
Liesbet Geris
8
12
Affiliations
1
EMA Modelling and Simulation Working Party, Amsterdam, The Netherlands.
2
Federal Agency for Medicines and Health Products, Brussels, Belgium.
3
Faculté des Sciences Pharmaceutiques, Université de Lubumbashi, Lubumbashi, DR Congo.
4
InSilicoTrials Technologies, Milano, Italy.
5
European Medicines Agency, Amsterdam, The Netherlands.
6
Medical Products Agency, Uppsala, Sweden.
7
Novadiscovery, Lyon, France.
8
KU Leuven, Leuven, Belgium.
9
Voisin Consulting Life Sciences, Boulogne (Paris), France.
10
Ansys, Wavre, Belgium.
11
AQuAS - Agency for Health Quality and Assessment of Catalonia, Catalonia, Spain.
12
Université de Liège, Liège, Belgium.
PMID:
32237207
PMCID:
PMC7179957
DOI:
10.1002/psp4.12504
No abstract available
Publication types
Research Support, Non-U.S. Gov't
MeSH terms
Computer Simulation / standards*
Drug Development / methods*
Humans
Models, Biological
Pharmacology
Systems Biology*
Validation Studies as Topic