Immunogenicity of cell death driven by immune effectors

Lorenzo Galluzzi; Giulia Petroni; Guido Kroemer

doi:10.1136/jitc-2020-000802

Immunogenicity of cell death driven by immune effectors

J Immunother Cancer. 2020 Apr;8(1):e000802. doi: 10.1136/jitc-2020-000802.

Authors

Lorenzo Galluzzi^{1

2

3

4

5}, Giulia Petroni⁶, Guido Kroemer^{7

8

9

10

11

12}

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA [email protected] [email protected].
² Sandra and Edward Meyer Cancer Center, New York, NY, United States.
³ Caryl and Israel Englander Institute for Precision Medicine, New York, NY, United States.
⁴ Department of Dermatology, Yale School of Medicine, New Haven, CT, United States.
⁵ Université de Paris, Paris, France.
⁶ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
⁷ Université de Paris, Paris, France [email protected] [email protected].
⁸ Equipe labellisée par la Ligue contre le cancer, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.
⁹ Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.
¹⁰ Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
¹¹ Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China.
¹² Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

Abstract

Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero's and Pardo's groups have now resolved this conundrum, demonstrating that T and NK cell-mediated cytotoxicity represents indeed a bona fide variant of immunogenic cell death.

Keywords: CD8-Positive T-Lymphocytes; cytotoxicity, immunologic; natural killer T-cells; receptors, chimeric antigen.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Cytotoxicity, Immunologic*
Immunogenic Cell Death*
Killer Cells, Natural