Hypovitaminosis D in lower extremity Joint Arthroplasty: A systematic review and meta-analysis

Ahmed K Emara; Emmanuel Nageeb; Jaiben George; Martin A Buttaro; Carlos Higuera; Nicolas S Piuzzi

doi:10.1016/j.jor.2020.03.010

Hypovitaminosis D in lower extremity Joint Arthroplasty: A systematic review and meta-analysis

J Orthop. 2020 Mar 25:21:109-116. doi: 10.1016/j.jor.2020.03.010. eCollection 2020 Sep-Oct.

Authors

Ahmed K Emara¹, Emmanuel Nageeb¹, Jaiben George¹, Martin A Buttaro², Carlos Higuera¹, Nicolas S Piuzzi^{1

3}

Affiliations

¹ Cleveland Clinic, Department of Orthopedic Surgery, 9500 Euclid Ave/A41, Cleveland, OH, 44195, USA.
² Hip Surgery Unit "Sir John Charnley", Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
³ Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Abstract

The purpose of the current systematic review was to identify the prevalence of hypovitaminosis-D in LE-TJA patients; and outline the association between pre-operative hypovitaminosis and post-operative outcomes. A search of PubMed-Medline and the Cochrane-Library databases was performed for literature published before November 27th, 2019. The eighteen studies analyzed had a pooled prevalence for vitamin D insufficiency (20 - <30 ng/mL) and deficiency (<20 ng/mL) of 53.4% and 39.4%, respectively. Hypovitaminosis-D was associated with higher complication rates (p = 0.043), and a greater prevalence among septic versus aseptic revisions (p = 0.016). Therefore, pre-operative screening for hypovitaminosis-D can be beneficial in patients undergoing LE-TJA.

Level of evidence: Systematic Review (Level III).

Keywords: Hypovitaminosis-D; Total hip arthroplasty; Total knee arthroplasty; Vitamin-D; Vitamin-D deficiency.

Publication types

Review