Delayed Relapse of Paracoccidioidomycosis in the Central Nervous System: A Case Report

Rifat Rahman; Leela Davies; Amir M Mohareb; Paula M Peçanha-Pietrobom; Nirav J Patel; Isaac H Solomon; David M Meredith; Harrison K Tsai; Jeffrey P Guenette; Shamik Bhattacharyya; Sebastian Urday; Gustavo E Velásquez

doi:10.1093/ofid/ofaa077

Delayed Relapse of Paracoccidioidomycosis in the Central Nervous System: A Case Report

Open Forum Infect Dis. 2020 Mar 2;7(4):ofaa077. doi: 10.1093/ofid/ofaa077. eCollection 2020 Apr.

Authors

Rifat Rahman¹, Leela Davies^{2

3

4}, Amir M Mohareb^{2

3

4}, Paula M Peçanha-Pietrobom⁵, Nirav J Patel⁶, Isaac H Solomon⁷, David M Meredith⁷, Harrison K Tsai⁷, Jeffrey P Guenette⁸, Shamik Bhattacharyya⁹, Sebastian Urday⁹, Gustavo E Velásquez^{2

10

11}

Affiliations

¹ Harvard Medical School, Boston, Massachusetts, USA.
² Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
³ Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁴ Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
⁵ Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil.
⁶ Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁷ Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁸ Division of Neuroradiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁹ Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
¹⁰ Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
¹¹ Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Abstract

Paracoccidioidomycosis is a dimorphic fungal infection endemic in Latin America. We report a patient with a history of pulmonary paracoccidioidomycosis who presented with relapsed disease in the central nervous system 4 years after initial treatment. We review current treatment strategies for paracoccidioidomycosis and neuroparacoccidioidomycosis.

Keywords: Paracoccidioides brasiliensis; central nervous system; endemic mycosis; neuroparacoccidioidomycosis; paracoccidioidomycosis.

Publication types

Case Reports

Abstract

Publication types

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