The First Case Report of Acute Symptomatic HEV Genotype 4 Infection in an HIV-positive Patient in Japan

Satoshi Kitaura; Yoshitaka Wakabayashi; Aiko Okazaki; Yuta Okada; Koh Okamoto; Mahoko Ikeda; Shu Okugawa; Kyoji Moriya

doi:10.2169/internalmedicine.4505-20

The First Case Report of Acute Symptomatic HEV Genotype 4 Infection in an HIV-positive Patient in Japan

Intern Med. 2020 Jul 1;59(13):1655-1658. doi: 10.2169/internalmedicine.4505-20. Epub 2020 Apr 9.

Authors

Satoshi Kitaura¹, Yoshitaka Wakabayashi^{1

2}, Aiko Okazaki¹, Yuta Okada¹, Koh Okamoto¹, Mahoko Ikeda³, Shu Okugawa¹, Kyoji Moriya^{1

3}

Affiliations

¹ Department of Infectious Diseases, The University of Tokyo Hospital, Japan.
² Department of Internal Medicine, Teikyo University, Japan.
³ Department of Infection Control and Prevention, The University of Tokyo, Japan.

Abstract

Hepatitis E virus (HEV) is a common cause of acute hepatitis. Four major genotypes of HEV have been studied, with genotype 4 being the predominant genotype across Asia. We herein describe the case of a 50-year-old man with a history of human immunodeficiency virus (HIV) infection who was admitted with acute transaminitis. Serum anti-HEV-IgA and HEV-RNA were detected at the time of presentation and further testing revealed HEV genotype 4. To the best of our knowledge, this represents the first clinical case report of acute symptomatic HEV genotype 4 infection in an HIV-positive patient in Japan.

Keywords: hepatitis E; hepatitis E virus; human immunodeficiency virus; men who have sex with men.

Publication types

Case Reports

MeSH terms

Antibodies, Anti-Idiotypic
Genotype
HIV Infections / complications*
HIV Seropositivity
Hepatitis E / complications*
Hepatitis E virus / genetics*
Humans
Japan
Male
Middle Aged
RNA, Viral / blood

Substances

Antibodies, Anti-Idiotypic
RNA, Viral
anti-IgA