Yeast Mycocins: a great potential for application in health

FEMS Yeast Res. 2020 May 1;20(3):foaa016. doi: 10.1093/femsyr/foaa016.

Abstract

Mycocins have demonstrated inhibition of fungi, bacteria, parasites and viruses, in addition to being studied as epidemiological markers and in the development of vaccines. They are defined as extracellular proteins or glycoproteins with different activities, the main mechanism of action being the inhibition of β-glucan synthesis in the cell wall of sensitive strains. Given the resistance problems created by several microorganisms to agents commonly used in clinical practice, the discovery of new substances with this purpose becomes essential. Mycocins have potential as anti-microbials because they show minimal toxicity and do not present resistance.

Keywords: antimicrobial; killer system; killer yeasts; mycocins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects
  • Cell Wall / drug effects
  • Fungal Proteins / chemistry
  • Fungal Proteins / pharmacology*
  • Humans
  • Mice
  • Mycotoxins / pharmacology*
  • Parasites / drug effects
  • Viruses / drug effects
  • Yeasts / chemistry*
  • Yeasts / metabolism

Substances

  • Anti-Infective Agents
  • Fungal Proteins
  • Mycotoxins