Survival risk score for real-life relapsed/refractory chronic lymphocytic leukemia patients receiving ibrutinib. A campus CLL study

Massimo Gentile; Fortunato Morabito; Giovanni Del Poeta; Francesca Romana Mauro; Gianluigi Reda; Paolo Sportoletti; Luca Laurenti; Marta Coscia; Yair Herishanu; Anna Grazia Recchia; Marzia Varettoni; Roberta Murru; Annalisa Chiarenza; Adalgisa Condoluci; Riccardo Moia; Daniela Pietrasanta; Giacomo Loseto; Ugo Consoli; Ilaria Scortechini; Francesca Maria Rossi; Antonella Zucchetto; Vincenzo Fraticelli; Ernesto Vigna; Cirino Botta; Giovanni Tripepi; Graziella D' Arrigo; Angela Rago; Ilaria Angeletti; Annalisa Biagi; Ilaria Del Giudice; Riccardo Bomben; Gian Matteo Rigolin; Davide Rossi; Francesco Di Raimondo; Gianluca Gaidano; Aaron Polliack; Antonio Cuneo; Robin Foà; Valter Gattei

doi:10.1038/s41375-020-0833-x

Survival risk score for real-life relapsed/refractory chronic lymphocytic leukemia patients receiving ibrutinib. A campus CLL study

Leukemia. 2021 Jan;35(1):235-238. doi: 10.1038/s41375-020-0833-x. Epub 2020 Apr 14.

Authors

Massimo Gentile^{1

2}, Fortunato Morabito^{3

4}, Giovanni Del Poeta⁵, Francesca Romana Mauro⁶, Gianluigi Reda⁷, Paolo Sportoletti⁸, Luca Laurenti⁹, Marta Coscia¹⁰, Yair Herishanu¹¹, Anna Grazia Recchia³, Marzia Varettoni¹², Roberta Murru¹³, Annalisa Chiarenza¹⁴, Adalgisa Condoluci¹⁵, Riccardo Moia¹⁶, Daniela Pietrasanta¹⁷, Giacomo Loseto¹⁸, Ugo Consoli¹⁹, Ilaria Scortechini²⁰, Francesca Maria Rossi²¹, Antonella Zucchetto²¹, Vincenzo Fraticelli^{22

3}, Ernesto Vigna^{22

3}, Cirino Botta^{22

3}, Giovanni Tripepi²³, Graziella D' Arrigo²³, Angela Rago²⁴, Ilaria Angeletti²⁵, Annalisa Biagi⁵, Ilaria Del Giudice⁶, Riccardo Bomben²¹, Gian Matteo Rigolin²⁶, Davide Rossi¹⁵, Francesco Di Raimondo¹⁴, Gianluca Gaidano¹⁶, Aaron Polliack²⁷, Antonio Cuneo²⁶, Robin Foà⁶, Valter Gattei²⁸

Affiliations

¹ Hematology Unit AO of Cosenza, Cosenza, Italy. [email protected].
² Biothecnology Research Unit, AO of Cosenza, Cosenza, Italy. [email protected].
³ Biothecnology Research Unit, AO of Cosenza, Cosenza, Italy.
⁴ Hematology Oncology Department, Augusta Victoria Hospital, East Jerusalem, Israel.
⁵ Division of Hematology, S. Eugenio Hospital and University of Tor Vergata, Rome, Italy.
⁶ Division of Hematology, Department of Translational and Precision Medicine, 'Sapienza' University, Rome, Italy.
⁷ Division of Ematologia, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
⁸ Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy.
⁹ Fondazione Universitaria Policlinico A Gemelli di Roma, Roma, Italy.
¹⁰ Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.
¹¹ Sourasky Medical Center, Institute of Hematology, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
¹² Division of Haematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
¹³ Hematology and Stem Cell Transplantation Unit, Ospedale A. Businco, Cagliari, Italy.
¹⁴ Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania, Catania, Italy.
¹⁵ Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
¹⁶ Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
¹⁷ Division of Hematology, Azienda Ospedaliera SS Arrigo e Biagio e Cesare Arrigo, Alessandria, Italy.
¹⁸ Hematology and Cell Therapy Unit, IRCCS-Istituto Tumori 'Giovanni Paolo II', Bari, Italy.
¹⁹ Department of Hematology, G. Garibaldi Hospital, Catania, Italy.
²⁰ Clinica di Ematologia Ospedali Riuniti, Ancona, Italy.
²¹ Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, (PN), Italy.
²² Hematology Unit AO of Cosenza, Cosenza, Italy.
²³ CNR-IFC, Research Unit of Reggio Calabria, Reggio Calabria, Italy.
²⁴ UOSD Ematologia ASL Roma 1, Roma, Italy.
²⁵ Reparto di Oncoematologia Azienda Ospedaliera Santa Maria di Terni, Terni, Italy.
²⁶ Hematology Section, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
²⁷ Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
²⁸ Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, (PN), Italy. [email protected].

PMID: 32286543
DOI: 10.1038/s41375-020-0833-x

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adenine / administration & dosage
Adenine / adverse effects
Adenine / analogs & derivatives*
Adenine / therapeutic use
Antineoplastic Agents, Immunological / administration & dosage
Antineoplastic Agents, Immunological / adverse effects
Antineoplastic Agents, Immunological / therapeutic use*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
Leukemia, Lymphocytic, Chronic, B-Cell / mortality*
Molecular Targeted Therapy
Piperidines / administration & dosage
Piperidines / adverse effects
Piperidines / therapeutic use*
Prognosis
Protein Kinase Inhibitors / administration & dosage
Protein Kinase Inhibitors / adverse effects
Protein Kinase Inhibitors / therapeutic use*
Treatment Outcome

Substances

Antineoplastic Agents, Immunological
Piperidines
Protein Kinase Inhibitors
ibrutinib
Adenine