E-cadherin deregulation in breast cancer

J Cell Mol Med. 2020 Jun;24(11):5930-5936. doi: 10.1111/jcmm.15140. Epub 2020 Apr 16.

Abstract

E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.

Keywords: E-cadherin; breast cancer; breast cancer metastases; breast cancer prognosis; breast cancer survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Breast Neoplasms / genetics*
  • Cadherins / genetics*
  • Cadherins / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Molecular Targeted Therapy
  • Prognosis

Substances

  • Biomarkers, Tumor
  • Cadherins