1 Department of Anaesthesiology and Intensive Care Medicine, University Medical Center Rostock, Rostock, Germany Queen Square Institute of Neurology, University College London, London, United Kingdom, and The National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital, London, United Kingdom, and Amsterdam UMC, Amsterdam, The Netherlands Neuro-anesthesiology and Intensive Care Medicine, Sainte-Anne Hospital, Paris-Descartes University, Paris, France, and Experimental neuropathology, Infection and epidemiology department, Institut Pasteur, Paris, France Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, TN, and Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, and Center for Health Services Research, The Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, and Tennessee Valley Veterans Affairs Healthcare System, Geriatric Research Education and Clinical Center (GRECC), Nashville, TN Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.